Characteristics of antimicrobial resistance and molecular epidemiology of Staphylococcus aureus isolated from patients in intensive care units
10.3969/j.issn.1671-9638.2016.05.002
- VernacularTitle:ICU患者分离金黄色葡萄球菌的耐药性及分子流行病学特征
- Author:
Xiuli XU
;
Shan ZHOU
;
Lu BAI
;
Jiayun LIU
;
Yueyun MA
;
Xiaoke HAO
- Publication Type:Journal Article
- Keywords:
intensive care unit;
Staphylococcus aureus;
staphylococcal protein A typing;
spa typing;
multilocus sequence typing;
MLST;
epidemiology;
drug resistance,microbial;
drug resistance
- From:
Chinese Journal of Infection Control
2016;15(5):294-298
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the characteristics of antimicrobial resistance and molecular epidemiology of Staphylococcus aureus (S .aureus)in the intensive care units(ICUs)of a hospital.Methods Clinical isolates of S .aureus collected from ICUs between January and December 2014 were identified and performed antimicrobial susceptibility testing,then typed by staphylococcal protein A (spa)typing and multilocus sequence typing (MLST) methods.Results Of 160 isolates of S .aureus ,120 (75.00%)were methicillin-resistant S .aureus (MRSA). Resistance rates of MRSA to erythromycin,clindamycin,and levofloxacin were all > 80%;methicillin-sensitive S .aureus (MSSA)were sensitive to cefazolin,resistance rates to erythromycin,clindamycin,and levofloxacin were 62.50%,35.00%,and 10.00% respectively.spa typing and MLST results showed that the main types of 120 isolates of MRSA were ST239-t030,ST239-t037,and ST5-t2460,the major epidemic strains were ST239-t030 (n=105,87.50%),and were isolated from 8 ICUs;MSSA had more types,ST59-t437 were detected only from depart-ment of neurology(n =8)and department of digestive diseases(n =2),ST6-t701 ,ST398-t3625,ST398-t1793,and ST121-t2092 were isolated from departments of neurology(n=7),anesthesiology(n=5),neurosurgery(n=4),and cardiac surgery(n=4)respectively.Conclusion Isolation rate of MRSA in ICUs in this hospital is high,ST239-t030 is the main type,which prevailed in hospital;different types of MSSA have epidemic trends in various departments.
