Comparison in prognosis of hospital-acquired pneumonia due to methicillin-resistant and methicillin-sensitive Staphylococcus aureus：analysis of propensity score matching
10.3969/j.issn.1671-9638.2016.05.003
- VernacularTitle:倾向指数配比分析（PSM）：MRSA 与 MSSA 医院获得性肺炎预后比较
- Author:
Wensen CHEN
;
Songqin LI
;
Huifen LI
;
Suming ZHANG
;
Bo LIU
;
Xiang ZHANG
;
Ping XU
;
Weihong ZHANG
- Publication Type:Journal Article
- Keywords:
propensity score matching;
hospital-acquired pneumonia;
Staphylococcus aureus;
methicillin-resis tant Staphylococcus aureus;
methicillin-sensitive Staphylococcus aureus;
disease burden
- From:
Chinese Journal of Infection Control
2016;15(5):299-303
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study whether methicillin-resistant Staphylococcus aureus (MRSA)will increase the burden of patients with hospital-acquired pneumonia (HAP).Methods Patients with Staphylococcus aureus HAP in a hospital between January 1 ,2013 and November 31 ,2014 were selected,patients with MRSA HAP were as case group,patients with methicillin-sensitive Staphylococcus aureus (MSSA)HAP were as control group,propen-sity score matching (PSM)analysis were conducted to compare the prognosis of MRSA HAP and MSSA HAP (length of hospital stay, duration from infection to discharge, mortality, total therapeutic cost ). Results APACHE II score in case group was higher than control group before PSM was conducted,length of hos-pital stay and duration from infection to discharge were both longer than control group (40[20,94]d vs 28[21 ,53] d;19[10,46]d vs 17[8,29]d,respectively,both P <0.05).APACHE II score in case group and control group af-ter conducting PSM was not significantly different(P >0.05 ),data were balanced and comparable;there were no significant difference in length of hospital stay between two groups (28[21 ,52]d vs 28[21 ,53]d),duration from in-fection to discharge (15[9,25]d vs17[8,29]d),mortality(10.87% vs 15.22%),and total therapeutic cost (121 013.5[80 747.21 ,176 200]yuan vs 119 911 .2[66 994.08,241 184.7]yuan)(all P >0.05).Conclusion APACHE II score is an important factor affecting prognosis;after balancing this factor,there is no difference in the prognosis of patients with MRSA and MSSA HAP,MRSA HAP can not increase the burden of disease.
