Role of Paired Immunoglobulin-like Receptor B in Nerve Regeneration (review)
10.3969/j.issn.1006-9771.2016.05.012
- VernacularTitle:配对免疫球蛋白样受体B与神经再生
- Author:
Lan XIAO
;
Yongtang WANG
;
Jingxiang WEI
;
Yahai SHU
;
Xiumin LU
;
Ying YU
- Publication Type:Journal Article
- Keywords:
paired immunoglobulin-like receptor B;
myelin-associated inhibitors;
axonal growth;
nerve regeneration;
review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2016;22(5):544-547
- CountryChina
- Language:Chinese
-
Abstract:
It is difficult for regeneration of central nervous system (CNS) in adult mammals, and myelin-associated inhibitors (MAIs) are believed to be major contributors. Paired immunoglobulin-like receptor B (PirB), as a co-receptor of MAIs, and expresses highly in CNS after injury, plays a vital role in the signal transduction of inhibition in the injured CNS. Knockout or block of PirB in vitro and in vivo may promote the neuro-regeneration after spinal cord injury or hypoxic-ischemic brain damage, release the damage induced byβ-amyloid in Al-zheimer's disease, recover the neural function in brain inflammation models, improve the reconstruction of vision after optic nerve injury, and so on. PirB may be a potential therapeutic target for neuro-regeneration and synaptic plasticity.
