Correlations of apparent diffusion coefficient with fibrosis and fibroblast activationprotein scores in pancreatic cancer
10.3969/j.issn.1002-1671.2016.05.015
- VernacularTitle:胰腺癌表观扩散系数与纤维化含量、成纤维细胞活化蛋白表达相关性研究
- Author:
Na LI
;
Yi HUAN
;
Jing REN
;
Yingmei WANG
;
Xin FU
;
Shunfan LIU
;
Jingjian WANG
;
Qing ZHAO
;
Bing HAN
;
Longlong WANG
;
Yanzhong GAO
- Publication Type:Journal Article
- Keywords:
pancreatic cancer;
apparent diffusion coefficient;
fibrosis;
fibroblast activation protein
- From:
Journal of Practical Radiology
2016;32(5):717-720
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlations of apparent diffusion coefficient (ADC) with fibrosis and fibroblast activation protein (FAP) score in pancreatic cancer .Methods Eighteen patients with pathologically confirmed pancreatic cancer were per‐formed conventional MR imaging ,DWI examinations .ADCs were measured with region of interest method on a “Single slice” .The wax blocks of 18 patients with pancreatic cancer were received Masson staining and FAP immunohistochemical staining .The correla‐tions of ADC with levels of fibrosis and FAP scores of pancreatic cancer were assessed by Pearson correlation analysis .Results The mild negative correlation between ADC value of cancerous foci and fibrosis was not significant (r= -0 .459 ,P=0 .056) .Significant negative correlation was found between ADC values of moderate and high differentiation cancerous foci and fibrosis (r= -0 .564 ,P=0 .044) .Significant negative correlation was found between ADC value and FAP score (r= -0 .497 , P=0 .036) .Conclusion The negative correlations are found between ADC and fibrosis ,FAP score of pancreatic cancer .DWI will be helpful to infer the pathologi‐cal characteristics .
