The experimental study of 3-day-old newborn rats with hypoxic-ischemic brain damage in MRI
10.3969/j.issn.1002-1671.2016.05.033
- VernacularTitle:3d 龄新生鼠缺氧缺血性脑损伤M RI 表现的实验研究
- Author:
Juan SONG
;
Xiaoan ZHANG
;
Xin ZHAO
;
Xin WANG
;
Xianglong LIU
- Publication Type:Journal Article
- Keywords:
hypoxic-ischemic;
brain damage;
diffusion weighted imaging;
triphenyl tetrazolium chloride staining
- From:
Journal of Practical Radiology
2016;32(5):788-791
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of MR diffusion imaging (DWI) appearance in newborn rats with hypoxic‐ischemic brain damage(HIBD) ,and its relationship with the changes of Triphenyl tetrazolium chloride (TTC) staining .Methods Using liga‐tion of the left carotid artery method to establish three different degrees of HIBD animal models ;DWI was performed at each time point(6-12 h ,12-24 h ,3 d ,7 d);Fresh brain tissue taken from another model groups of newborn rats in 12 h ,24 h ,3 d ,7 d were staining in TTC ,then we observed its relationship with DWI .Results The lesion location of three model groups mainly distributed in the left side of cortex and subcortical region ,with prolonged hypoxia time ,hippocampus ,lateral side white matter ,thalamus were also have varying degrees of involvement .The right side of the cortex and subcortical in some cases involved .TTC staining showed posi‐tive results in 3 d ,its loss stained area were consistent with DWI abnormal signal area .Conclusion DWI can be evaluation of HIBD lesions early .The early lesions of HIBD mainly distributed in the left side of cortex and subcortical region .
