Correlation between prostacyclin synthase gene rs5602 polymorphism and ischemia stroke in Chinese Han population
10.3760/cma.j.issn.1673-4165.2016.03.003
- VernacularTitle:前列环素合酶基因 rs5602多态性与中国汉族人群缺血性卒中的相关性
- Author:
Yingying LIU
;
Xingyang YI
;
Chun WANG
;
Jing LIN
- Publication Type:Journal Article
- Keywords:
Stroke;
Brain Ischemia;
Cytochrome P-450 Enzyme System;
Polymorphism,Genetic;
Spectrometry,Mass,Matrix-Assisted Laser Desorption-Ionization;
Prostacyclin Synthetase
- From:
International Journal of Cerebrovascular Diseases
2016;24(3):205-209
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between prostacyclin synthase (prostaglandin I2 synthase, PGIS) gene rs5602 single nucleotide polymorphism and ischemia stroke in Chinese Han population. Methods The patients with ischemia stroke and healthy controls in Chinese Han population were enroled. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI TOF MS) was used to detect the rs5602 polymorphism. Results A total of 297 patients with ischemic stroke (male 177 and female 120) and 291 healthy controls (male 165, female 126) over the same period were enroled. The frequencies of TT genotype (31. 1% vs. 43. 6% ; χ2 = 5. 773, P = 0. 016) and T alele (56. 8% vs. 65. 8% ; χ2 = 5. 793, P = 0. 016) in the male patients with ischemic stroke were significantly lower than those in the male healthy controls. Multivariate logistic regression analysis showed that the rs5602 TT genotype was a protective factor for ischemic stroke in male (odds ratio 0. 260, 95% confidence interval 0. 118-0. 570; P = 0. 001). Conclusions PGIS gene rs5602 polymorphism is associated with ischemic stroke in male in Chinese Han population.
