Role of caveolins in the blood-brain barrier disruption after cerebral ischemia
10.3760/cma.j.issn.1673-4165.2016.03.013
- VernacularTitle:陷窝蛋白在脑缺血后血脑屏障破坏中的作用
- Author:
Zhaojun WANG
;
Liumin WANG
;
Ying LIN
;
Yahong LIU
- Publication Type:Journal Article
- Keywords:
Stroke;
Brain Ischemia;
Blood-Brain Barrier;
Brain Edema;
Caveolin 1
- From:
International Journal of Cerebrovascular Diseases
2016;24(3):254-258
- CountryChina
- Language:Chinese
-
Abstract:
Caveolins are the major component proteins of the caveolae, and they are also the essential proteins to carry out the physiological functions of caveolae. Caveolins are expressed in smooth muscle cels, endothelial cels, and adipocytes. Caveolae are not only involved in the basic physiological processes, such as celular fat intake, endocytosis, and pinocytosis, but also play a very important role in cel signal transduction and transport and permeability of macromolecular substance. With the in-depth research on the molecular structure and biochemical function of caveolins, increasing studies have shown that caveolae and their main component caveolins play an important role in the pathophysiological process of cerebrovascular diseases. This article reviews the roles of caveolins in the blood-brain barrier destruction after cerebral ischemia.
