Polymorphisms of elastin and collagen type Ⅰ α2 genes and intracranial aneurysm rupture
10.3760/cma.j.issn.1673-4165.2016.03.017
- VernacularTitle:弹性蛋白和Ⅰ型胶原α2基因多态性与颅内动脉瘤
- Author:
Xiaojuan NIE
;
Jingfen ZHANG
- Publication Type:Journal Article
- Keywords:
Intracranial Aneurysm;
Subarachnoid Hemorrhage;
Polymorphism,Genetic;
Elastin;
Colagen Type Ⅰ
- From:
International Journal of Cerebrovascular Diseases
2016;24(3):272-274
- CountryChina
- Language:Chinese
-
Abstract:
Intracranial aneurysms are mainly caused by the local arterial wal defects and the increased intraluminal pressure. Usualy, the unruptured smal aneurysms are asymptomatic, and the ruptured aneurysms can cause subarachnoid hemorrhage. So far, the etiology and pathogenesis of intracranial aneurysms are not fuly understood. A lot of evidence has showed that intracranial aneurysms are a complex disease of environmental factors and multi-gene interaction. This article reviews the correlation between polymorphisms of elastin and colagen type Ⅰ α2 genes and intracranial aneurysm.
