Roles and mechanism of inflammation in intracranial aneurysm formation and rupture
10.3760/cma.j.issn.1673-4165.2016.03.018
- VernacularTitle:炎症在颅内动脉瘤形成和破裂中的作用和机制
- Author:
Pengfei YAO
;
Gang CHENG
;
Chen GAO
- Publication Type:Journal Article
- Keywords:
Intracranial Aneurysm;
Aneurysm,Ruptured;
Inflammation
- From:
International Journal of Cerebrovascular Diseases
2016;24(3):275-278
- CountryChina
- Language:Chinese
-
Abstract:
Inflammation is involved in the pathogenesis of many vascular disorders. Hemodynamics cause the activation of inflammatory factors in the vascular wal , resulting in dysfunction of vascular endothelial cels and vascular smooth muscle cels, activating vascular wal inflammatory cascade. Inflammatory cels, especialy macrophage infiltration and secretion of enzymes gradualy weaken the vessel wal to form aneurysm, and even cause aneurysm rupture. Therefore, inflammation plays a key role in the formation and rupture of intracranial aneurysms.
