Roles of macrophages in intracranial aneurysm
10.3760/cma.j.issn.1673-4165.2016.03.019
- VernacularTitle:巨噬细胞在颅内动脉瘤中的作用
- Author:
Weilin RONG
;
Xi XIAO
;
Meihua LI
- Publication Type:Journal Article
- Keywords:
Intracranial Aneurysm;
Macrophages;
Inflammation
- From:
International Journal of Cerebrovascular Diseases
2016;24(3):279-283
- CountryChina
- Language:Chinese
-
Abstract:
Inflammation plays a key role in the formation of intracranial aneurysm. At present, the pathophysiological processes of intracranial aneurysms are mainly caused by both hemodynamic abnormalities and inflammation. Studies have shown that the inflammatory cels in the intracranial aneurysm wal are mainly mononuclear macrophages, and can secrete various effector molecules, weakening and destroying the structures of the vessel wal . Therefore, the research of the roles of differences played in different subtypes of macrophages and their effector molecules in the pathophysiological processes of intracranial aneurysms wil provide clues for exploring the pathogenesis of intracranial aneurysms and effective targeted therapy.
