Prognosis of breast cancer with low-positive hormonal receptors using epidermal growth factor receptor and cytokeratin 5/6 as indi-cators
10.3760/cma.j.issn.1674-6090.2016.02.003
- Author:
Jianyi LI
;
Jinqi XUE
;
Wenhai ZHANG
;
Yang ZHANG
;
Shi JIA
;
Songying QIAN
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Hormone receptor;
Epidermal growth factor receptor;
Cytokeratin 5/6;
Endocrine therapy;
Prognosis
- From:
Chinese Journal of Endocrine Surgery
2016;10(2):106-117
- CountryChina
- Language:Chinese
-
Abstract:
Objective Less than a decade ago, ER-positive and PgR-positive diagnostic criteria decrease from 10%to 1%. Up to 20%of current immunohistochemical determinations of ER and PgR worldwide may be inaccu-rate. It is necessary to study patients whose tumors are between luminal A (LABC) and triple-negative (TNBC) breast cancer. Methods Survival analysis grouping by the level of positive hormone receptor, CK5/6 and EGFR, and en-docrine therapy was carried out in 206 patients whose tumors were junction zone between LABC and TNBC. Re-sults There were no significant differences between the low-positive (1%-9%) HR group and positive HR (10%-19%) group in overall survival (OS) and disease-free survival (DFS). There was an apparent difference between the nor-mal-like group and basal-like group in OS and DFS, and between the patients with and without endocrine therapy. There were significant differences between death and tumor progression for EGFR and CK5/6, chemotherapy, and endocrine therapy. Conclusions We conclude that EGFR and CK5/6 are better prognostic indicators than the lev-el of positive HR in patients whose tumors are junction zone at the junction zone between LABC and TNBC. En-docrine therapy can be highly beneficial to these patients regardless of the positive HR level.
