Investigation of underestimated malignancy in patients with intraductal papillary tumors by core needle biopsy
10.3760/cma.j.issn.1674-6090.2016.02.006
- VernacularTitle:空芯针活检为乳腺导管内乳头状瘤的病理低估研究
- Author:
Long SUN
;
Xiaosong CHEN
;
Jiayi WU
;
Ou HUANG
;
Yue LIANG
;
Yafen LI
;
Weiguo CHEN
;
Li ZHU
;
Jianrong HE
;
Kunwei SHEN
- Publication Type:Journal Article
- Keywords:
Core needle biopsy;
Intraductal papillary tumors;
Breast cancer;
Pathological underes-timation;
Predictors
- From:
Chinese Journal of Endocrine Surgery
2016;10(2):129-134
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To calculate the rate of pathological underestimation for core needle biopsy (CNB)- diagnosed intraductal papillary tumors, to analyze the clinical and imaging data of patients and to dis-cuss factors for underestimation. Methods A retrospective analysis of patients undergoing core needle biopsy and subsequent surgical excision was performed. 1359 female patients undergoing CNB from Jan. 2010 to Feb. 2013 in Comprehensive Breast Health Center of Ruijin hospital were analyzed. Clinical, radiological and histo-logical variables were assessed using the Chi-square test, Fisher’s exact test and a binary logistic regression model in order to predict pathological underestimation for tumors. Results There were 50 patients with CNB-di-agnosed intraductal papillary tumors. The overall underestimation rate was about 44%(22/50). CNB-diagnosed atypical papillary lesions (OR=15.164, 95% CI 1.49-170.443) and BI-RADS 5 by MRI (OR=26.766, 95% CI 2.409-297.440)were significantly related to underestimation in these patients. Conclusions Considering the high underestimation rate in CNB-diagnosed intraductal papillary tumors, routine surgical excision should be per-formed to avoid potential malignancy, especially for patients with high risk factors. MRI is helpful in these pa-tients to predict underestimation.
