Association of urinary podocalyxin and vascular endothelial growth factor levels with oxidative stress in patients with type 2 diabetes nephropathy
10.3969/j.issn.1671-8348.2016.10.011
- VernacularTitle:2型糖尿病肾病患者尿足细胞标志蛋白和血管内皮生长因子水平与氧化应激的相关性
- Author:
Shanshan DONG
;
Jie ZHANG
;
Fan LIU
;
Yujing MI
;
Xinpan LI
;
Huimin ZHOU
- Publication Type:Journal Article
- Keywords:
diabetic nephropathy;
podocytes;
vascular endothelial growth factor;
oxidative stress
- From:
Chongqing Medicine
2016;45(10):1334-1336
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change of urinary podocalyxin(PCX) and vascular endothelial growth factor (VEGF) levels and its association with the oxidative stress in the patients with type 2 diabetes mellitus(T2DM ) complicating dif‐ferent degrees of diabetic nephropathy .Methods Totally 186 patients with T2DM were divided into the pure T2DM (SDM ,62 ca‐ses) ,trace amount group(NA group ,60 cases) and massive amount group(MA group ,64 cases) according to the 24 h urinary albu‐min excretion rate(UAER) .60 cases of normal 24 h UAER were taken as the control group(NC group) .The levels of PCX ,VEGF , superoxide dismutase (SOD) ,malondialdehyde(MDA) and glutathione peroxidase (GSH‐px)were determined .Results Compared with other three groups ,the level of VEGF ,PCX and MDA in the MA group were highest(P<0 .01) ,while the levels of SOD and GSH‐px were lowest(P<0 .01 ,P<0 .05) .VEGF ,UAER ,HbA1c were the independent risk factors for urinary PCX .Conclusion In patients with diabetic nephropathy ,urinary PCX and VEGF are correlated with the oxidative stress ,while the oxidative stress is closely correlated with glomerular podocyte injury .
