Clinical efficacy and safety of rabeprazole in combined with flupentixol melitracen in treatment of non -erosive gastroesophageal reflux disease with anxiety and depression
10.3760/cma.j.issn.1008-6706.2016.10.006
- VernacularTitle:雷贝拉唑联合氟哌噻吨美利曲辛治疗非糜烂性胃食管反流病伴焦虑抑郁的临床疗效和安全性
- Author:
Chunhong XU
- Publication Type:Journal Article
- Keywords:
Rabeprazole;
Flupentixol melitracen;
Non -erosive gastroesophageal reflux disease;
Anx-iety and depression
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(10):1459-1462
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy and safety of rabeprazole in combined with flupentixol melitracen in treatment of non -erosive gastroesophageal reflux disease with anxiety and depression.Methods 84 cases with non -erosive gastroesophageal reflux disease with anxiety and depression of outpatient and inpatient admitted from October 2012 -October 2013 and they were randomly divided into two groups according to the order,all had 42 cases.The control group was given rabeprazole treatment,observation group used flupentixol melitracen treat-ment on the basis of the control group.The clinical efficacy and the occurrence of adverse reactions of the two groups were compared.Results The total effective rate of the observation group was 95.24%,which was significantly higher than 76.19% in the control group,the difference was significant (χ2 =11.20,P <0.05).After treatment,HAMD score (7.64 ±2.58)and HAMA score (5.60 ±2.41)of the observation group were significantly lower than HAMD (21.72 ±2.96)and HAMA scores (14.32 ±2.59)of the control group,the differences were significant (t =9.66, 10.04,all P <0.05).The incidence rate of adverse reaction of the observation group (14.29%)compared with the control group (16.67%),had no statistically significant difference (χ2 =1.29,P >0.05 ).Conclusion Rabe-prazole in combined with flupentixol melitracen in treatment of non -erosive gastroesophageal reflux disease with anxi-ety and depression had good effect,and the adverse reactions were mild and safe.
