Correlation between apolipoprotein E gene polymorphism in Yu patients and cerebral infarction in Taishun county of Zhejiang province
10.3760/cma.j.issn.1008-6706.2016.10.024
- VernacularTitle:载脂蛋白E基因多态性与浙江省泰顺县畲族患者脑梗死的相关性研究
- Author:
Xiaoguo YANG
;
Zhiguang GONG
;
Yanyan ZHENG
;
Yu TONG
;
Yijun LIN
- Publication Type:Journal Article
- Keywords:
Gene polymorphism;
Apolipoprotein E;
Cerebral infarction
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(10):1523-1526
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between apolipoprotein E gene polymorphism and cerebral infarction in Taishun county.Methods Determination of 112 cases of Taishun Siqian cerebral infarction patients and healthy persons 88 cases of ApoE gene polymorphism,and the cerebral infarction patients were admitted to the hospital for different period of time after the NIHSS score.Results The cerebral infarction group and the control group were ApoE -/3 genotype most were 70.5%(79 /112)and 63.6%(56 /88),both had significant difference(P >0.05);The cerebral infarction group and the control group in terms of ApoE -up to 3,respectively 82.1%(92 /112)and 75.6%(66.5 /88),both had no significant difference (P >0.05).The cerebral infarction group epsilon 4 to 9.8%(11 /112),and was significantly higher than that of the control group 4.0%(3.5 /88);E2 was 6.2% (7 /112), which was significantly lower than that of the control group [19.3% (17 /88)],the differences were significant (χ2 =6.189,7.970,all P <0.05).Carrying ApoE -4 of the cerebral infarction patient each time period at the time of admission,admission 7d and 14d NIHSS scores were not carrying epsilon 4 patients increased significantly (t =7.853,6.185,5.165,allP <0.05);and at each time point carrying epsilon 2 gene in patients with and without carry-ing epsilon 2 patients NIHSS scores had no significant difference (P >0.05 ).Conclusion Cerebral infarction patients ApoE gene polymorphism and disease progression and prognosis are closely related,ApoE -4 Taishun Siqian cerebral infarction patients predisposing factors.At the same time,the detection of apoE genotype and NIHSS score is helpful to the prognosis of the patients.
