Curative effects of high -dose glucocorticoids combined with short -range hormone therapy for patients with myasthenia gravis
10.3760/cma.j.issn.1008-6706.2016.10.031
- VernacularTitle:大剂量糖皮质激素冲击后联合短程激素综合治疗重症肌无力的疗效观察
- Author:
Shanshan YU
- Publication Type:Journal Article
- Keywords:
Myasthenia gravis;
Glucocorticosteroids;
Combined modality therapy
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(10):1549-1552
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the curative effects and clinical safety of high -dose glucocorticoids (GCS)combined with short -range hormone therapy for myasthenia gravis(MG).Methods The clinical data of 68 patients with MG were retrospectively analyzed.They were divided into the control group and the observation group (34 cases in each group)according to different treatment methods.The control group was treated by high -dose GCS combined with long -term hormone therapy,while the observation group received large doses of GCS short -range hormone treatment combined with other immunosuppressive therapy.Before and after treatment,curative effects and adverse reactions of the two groups were recorded and compared.Results The onset time of the control group and the observation group was respectively (7.8 ±3.5)days,(8.2 ±4.2)days;Before treatment,and after 4 weeks,8 weeks, 12 weeks treatment,the clinical absolute scores of the control group were (24.7 ±10.5)points,(15.4 ±6.3)points, (6.8 ±5.4)points,(7.1 ±4.5 )points,which of the observation group were (25.2 ±11.1 )points,(16.9 ± 7.1)points,(7.4 ±4.8)points,(8.3 ±5.5)points.The onset time and clinical absolute scores of the two groups had no statistical differences(t =0.978,0.925,0.897,1.213,all P >0.05);After 4 weeks of treatment and 12 weeks of treatment,the total effective rates in the control group were 85.3%,94.1% respectively,which of the observation group were 76.5%,91.2% respectively,the two groups had no statistically significant differences (χ2 =0.856, 0.216,all P >0.05);The incidence rate of adverse reactions in the control group (38.2%)was significantly higher than 14.7% in the observation group(χ2 =4.836,P <0.05).Conclusion Large dose of GCS combined with short-range hormone has adequate curative effects compared with large dose of GCS long -range hormone for the treat-ment of myasthenia gravis,but it had the lower incidence of adverse reactions,which is worthy of clinical promotion.
