Effect of Tongqiaoxingnao soup in the treatment of elder severe craniocerebral injury stasis resistance qing qiao patients
10.3760/cma.j.issn.1008-6706.2016.09.011
- VernacularTitle:通窍醒脑汤佐治老年人重度颅脑损伤瘀阻清窍证的疗效观察
- Author:
Wanglan XU
;
Xiaoying YAO
;
Baizhi PI
;
Juanjuan XUAN
;
Jun YAO
- Publication Type:Journal Article
- Keywords:
Craniocerebral trauma;
Stasis resistance qing qiao;
Tongqiaoxingnao soup;
Treatment outcome
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(9):1321-1324
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect and safety of Tongqiaoxingnao soup applied in elder severe craniocerebral injury stasis resistance qing qiao patients.Methods 40 cases with severe craniocerebral injury stasis resistance qing qiao were enrolled in the study,and they were divided into two groups randomly,each group had 20 cases.Patients in the monotherapy group received routine western medicine treatment,while the combination group was added the treatment of Tongqiaoxingnao soup,200mL per day for 4 weeks.GCS scores and the persistent time of coma were analyzed.After treatment for 4,8,14 days of intracranial pressure and cerebral edema were recorded and analyzed,the total effective rate and the incidence of adverse reactions were compared between two groups.Results GCS score of the combination group was (13.7 ±4.2)points,and it was obviously higher than the monotherapy (9.2 ±3.5)points (t =2.86,P <0.05).The coma duration of the combination group was (6.5 ±1.4)d,and it was obviously shorter than the monotherapy group (10.2 ±2.5 )d (t =2.86,P <0.05 ).The amount of intracranial pressure increased of combination group were 10 cases and 8 cases,which were significantly less than the monotherapy after 8 and 14 days with 16 cases and 15 cases (χ2 =3.96,5.01,all P <0.05).Total effective rate of combination treatment group was 75.0%,which was significantly higher than 40.0% of monotherapy group (χ2 =5.01,P <0.05).The occurrence of adverse reactions such as bleeding,electrolyte imbalance,hypoxemia,and the acid -base imbalance had no significant differences between the two groups (P >0.05 ).Conclusion Tongqiaoxingnao soup applied in elder severe craniocerebral injury stasis resistance qing qiao patients has clinical curative effect,can shorten the coma time,reduce intracranial pressure and relieve cerebral edema,and has high security,it is worthy of populari-zation and application.
