Effect of calcitriol pulse therapy on maintenance hemodialysis patients 'microinflammation and oxidative stress
10.3760/cma.j.issn.1008-6706.2016.09.020
- VernacularTitle:骨化三醇冲击治疗对维持性血液透析患者微炎症及氧化应激状态的影响
- Author:
Chunming LI
- Publication Type:Journal Article
- Keywords:
Hemodiafiltration;
Calcitriol;
Inflammation;
Oxidative stress
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(9):1357-1361
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of calcitriol pulse therapy on maintenance hemodialysis patients'microinflammation and oxidative stress.Methods The clinical data of 106 patients with maintenance hemo-dialysis were retrospectively analyzed.106 patients were randomly divided into two groups,each group had 53 cases. The observation group was treated with high dose pulse oral calcitriol therapy(2.0μg,twice a week),while the control group received conventional calcitriol therapy (0 .5 μg ,qd ).Both two groups were treated for 12 weeks.Then,the levels of iPTH,serum calcium and phosphorus,microinflammation and oxidative stress before and after treatment were compared.Results There was no difference between the two groups in iPTH indicators(t =0.354,P >0.05).After treatment,the levels of iPTH,hs -CRP,IL -6,TGF -β1,MDA,MPO in both two groups all decreased(t =7.678, 7.417,13.663,25.709,16.114,9.940,all P <0.001;t =2.130,3.006,5.945,12.961,7.367,4.567,all P <0.01),the levels of GSH -PX all increased(t =13.173,P <0.001;t =4.815,P <0.001),and there were signifi-cant differences between the two groups (t =10.326,P <0.001;t =3.601,P <0.001;t =9.263,P <0.001;t =11.094,P <0.001;t =8.262,P <0.001;t =3.693,P <0.001;t =9.289,P <0.001).The levels of serum calcium and Ca ×P remained unchanged in 4 and 8 weeks(t =1.354,0.128,0.992,0.879,all P >0.05;t =0.777,1.310, 1.210,1.957,all P >0.05 ),which of the observation group were significantly higher than the control group in 12 weeks(t =2.805,P =0.006;t =3.070,P =0.002).Conclusion For treatment of patients with maintenance hemodialysis,calcitriol pulse therapy can reduce systemic microinflammatory response and enhance antioxidant capacity.
