The change trend of inflammatory mediators and oxidative stress markers after autologous orthotopic liver transplantation of rat
10.3969/j.issn.1006-5725.2016.07.014
- VernacularTitle:大鼠自体原位肝移植术后肺部炎症以及氧化应激标志物变化趋势
- Author:
Qianqian ZHU
;
Fei HUANG
;
Yihan ZHANG
;
Weifeng YAO
;
Jun CAI
- Publication Type:Journal Article
- Keywords:
Autologous orthotopic liver transplantation;
Inflammatory mediators;
Oxidative stress
- From:
The Journal of Practical Medicine
2016;32(7):1077-1080
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the pathological changes of lung, expression of the relevant inflammatory factors and oxidative stress markers of Sprague-Dawley (SD) rats undergoing autologous orthotopic liver transplantation (AOLT). Methods Thirty SD rats were randomized into sham group and AOLT group. The pathological changes of lung, expression of the relevant inflammatory mediators and oxidative stress markers were detected . Results ( 1 ) Compared with the sham group , the pathological scores of lung tissue in AOLT group increased significantly and reached its peak at 8 h after surgery. Then the pathological scores decreased to the level of sham within 24 h to 48 h after surgery; (2)The relative expression of inflammatory mediators including TNF-α, IL-1β, IL-6 and IL-8 increased significantly and reached its peak at 8 h after surgery in AOLT group. Then decreased to the level of sham group within 24 h to 48 h after surgery; (3)The change trends of MDA and H2O2 were similar to inflammatory mediators.The relative SOD expression decreased significantly and touched the nadir at 8h after surgery and then increased. Conclusion The pathological changes of lung expression, the relevant inflammatory mediators and oxidative stress markers of rats underwent AOLT were consistent.
