The correlation between TLR2 gene -597T/C polymorphism and primary ANCA associated small vasculitis of Han population in Guangxi
10.3969/j.issn.1006-5725.2016.07.018
- VernacularTitle:广西汉族人群Toll样受体2（597T／C）基因多态性与ANCA相关性小血管炎的关系
- Author:
Suzhen WEI
;
Chao XUE
;
Yunhua LIAO
;
Yanfei LAI
;
Chunxiang WU
;
Linlin HE
;
Aimei GONG
- Publication Type:Journal Article
- Keywords:
ANCA associated small vasculitis;
TLR2;
Single nucleotide polymorphism;
Gentic risk
- From:
The Journal of Practical Medicine
2016;32(7):1092-1096
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between Toll-like receptor2 (TLR2) gene promoter region -597T/C polymorphism and primary ANCA associated small vasculitis (AAV) in Guangxi Han people. Methods A case contrastive control study was adopted in the study. Patients with AAV (patients group, n=110) and healthy people (control group, n = 200) were recruited. Associated serum indexes were detected and polymorphisms of TLR2 gene promoter 597T/C were analyzed by polymerase chain restricted fragment length polymorphisms (PCR-RFLP). Results (1)Three TLR2-597T/C genotypes were discovered in 110 AAV patients, namely, TT, TC and CC, with the frequency of 54.55%,40.00% and 5.45% respectively. And the frequencies of allele T and C were 74.55% and 25.45%. In control group, the genotype frequencies of TT, TC and CC were 56.00%,40.50% and 3.50%, with 76.25% of allele T and 23.75% of allele C. No significant differences were found in neither genotype distribution nor allele frequencies between the patients group and control group ( P > 0 . 05 ) . ( 2 ) Significant differences were found in the incidence of proteinuria rate and the hemoglobin (P< 0.05)in AAV patients. (3)There was no significant difference between AI and CI in TT, TC and CC genotype in AAV patients. Conclusions Polymorphism of TLR2-597T/C may be correlated with the incidence of proteinuria and the level of hemoglobin, while no obvious correlation with the genetic susceptibility of ANCA in vasculitis patients of Guangxi Han people.
