Association between Q-1, T2 locus allele in ADAM33 gene and chronic obstructive pulmonary disease in Xinjiang Kazak, Han population
10.3969/j.issn.1006-5725.2016.07.020
- VernacularTitle:ADAM33基因Q-1、T2位点多态性与新疆哈萨克族、汉族人群慢性阻塞性肺疾病易感性的关系
- Author:
Shasha WANG
;
Jian GUAN
;
Shan WANG
;
Fangjuan CHENG
;
Xia REN
- Publication Type:Journal Article
- Keywords:
Chronic obstructive;
Pulmonary disease;
Haplotype;
ADAM33 gene;
Polymorphism
- From:
The Journal of Practical Medicine
2016;32(7):1100-1103
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship of the ADAM33 gene Q-1,T2 single nucleotide polymorphism (SNP) and suffering from chronic obstructive pulmonary disease (COPD) in Xinjiang Kazakh and Han population. Methods Peripheral blood samples to extract DNA, and the single nucleotide polymorphisms of Q-1 and T2 in ADAM33 gene were detected by SNaPshot SNP genotyping. Results Case group compared with the control group, frequencies of Q-1 locus genotypes and alleles were significant differences in Kazak (P<0.05). In patient group, there were significant differences in ADAM33 gene Q-1 locus genotypes FEV1% predicted, FEV1/FVC of clinical indicators lung function in Kazak, Han(P < 0.05). Kazak Q-1 locus AA genotype,Han GA genotype than GG genotype were significant difference.Compare Kazak AA genotype,Han GA genotype with GG genotype is more likely to cause COPD in Q-1 locus(P<0.05). In the comparison of the case and control group the two ethnic, there was no significant difference between the frequencies of T2 locus genotypes and the frequencies of Q-1,T2 the alleles (P > 0.05). There were no significant differences in T2 locus genotypes and clinical indicators of lung function FEV1% predicted and FEV1/FVC in patient group (P > 0.05). Conclusion The ADAM33 gene Q-1 locus may be related to the COPD susceptibility in Xinjiang Kazak, Han.
