Protection of Qimei Fermented Beverage against alcohol-induced liver injury in mice
10.3969/j.issn.1671-8348.2016.10.008
- VernacularTitle:奇魅植物酵素对小鼠酒精性肝损伤保护作用的研究
- Author:
Jun WANG
- Publication Type:Journal Article
- Keywords:
Qimei fermented beverage;
liver disease,alcoholic;
protective effect
- From:
Chongqing Medicine
2016;45(10):1323-1325
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the protective effect of Qimei Fermented Beverage against alcohol‐induced liver injury in mice .Methods Alcohol‐induced liver injury mouse model was established by continuously intragastric administration .Totally 60 male mice were randomly divided into five groups ,blank control group ,model group ,low ,middle and high doses groups(adding 5 , 25 ,50 mL/kg Qimei Fermented Beverage) .After continuous intragastric administration for 9 weeks ,the levels of serum aspartate transaminases(AST ) and alanine transaminases (ALT ) were detected in each group ,moreover the levels of malondialdehyde (MDA) ,triglyceride(TG) ,glutathione(GSH) and alcohol dehydrogenase(ADH) ,aldehyde dehydrogenase (ALDH) of liver ho‐mogenate ,and liver index change were measured .Liver histopathological changes were observed .Results The alcohol‐induced liver injury model in mice was successfully established .Compared wit model group ,different doses groups of Qimei Fermented Beverage could effectively reduce the levels of serum AST ,ALT and liver tissue TG ,increased the levels of ADH ,ALDH ,GSH .In addition , the pathological examination results of liver were consistent with those in enzymology .Conclusion Qimei Fermented Beverage has certain protective effect against alcohol‐induced liver injury and can obviously improve the alcohol‐induced liver injury .
