Curative efficacy of L -glutamine gung shimron acid sodium in combination with esomeprazole in the treat-ment of pediatric peptic ulcer and its effects on immunological function and intestinal flora
10.3760/cma.j.issn.1008-6706.2016.10.001
- VernacularTitle:L-谷氨酰胺呱仑酸钠联合埃索美拉唑治疗小儿消化性溃疡疗效及对患儿免疫功能和肠道菌群的影响
- Author:
Chengzhi TENG
;
Lingling LUO
;
Chunli ZHANG
- Publication Type:Journal Article
- Keywords:
Pediatric peptic ulcer;
L -glutamine gung shimron acid sodium;
Esomeprazole;
Immune function;
Intestinal flora
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(10):1441-1444
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of L -glutamine gung shimron acid sodium in combi-nation with esomeprazole in the treatment of pediatric peptic ulcer and its effects on immunological function and intes-tinal flora.Methods 120 patients of pediatric peptic ulcer meeting the inclusion criteria were randomly divided into two groups equally.Besides conventional treatments,the control group was treated with esomeprazole,and the observa-tion group was treated with L -glutamine gung shimron acid sodium in combination with esomeprazole.After the course of treatment,the curative efficacy was compared after the eight -week follow -up.Before and after the treat-ment,T lymphocyte subpopulation (CD +4 ,CD +8 ,CD +4 /CD +8 )reflecting cellular immune function,intestinal flora and adverse reactions were compared.Results After the eight -week follow -up,the total effective rate of the observa-tion group was 96.7%,which was significantly higher than 86.7% of the control group (χ2 =3.93,P <0.05).After treatment,levels of CD +4 [(43.5 ±6.6)% vs (40.9 ±6.2)%],CD +4 /CD +8 [(1.72 ±0.38)vs (1.38 ±0.45)] were statistically higher and level of CD +8 [(26.2 ±3.7)% vs (30.1 ±5.0)%]was statistically lower in the obser-vation group in comparison with the control group (t =2.22,P <0.05;t =4.47,t =4.86,P <0.01).As to intestinal flora,the observation group had statistically higher concentration of lactobacillus [(7.5 ±1.3 )LonN /g feces vs (5.8 ±1.2)LonN /g feces],bifidobacterium[(8.3 ±1.1)LonN /g feces vs (6.6 ±1.4)LonN /g feces]in the feces in comparison with the control group after treatment (t =7.44,t =7.40,both P <0.05).During the treatment,there were no severe adverse reactions.Conclusion L -glutamine gung shimron acid sodium in combination with esome-prazole is effective for pediatric peptic ulcer,which can significantly increase curative efficacy,enhance cellular immune function and effectively regulate intestinal flora with minor adverse reactions.
