The clinical efficacy and safety of Ganluxiaodu micropills in treatment of Hp infected chronic atrophic gastritis
10.3760/cma.j.issn.1008-6706.2016.10.002
- VernacularTitle:甘露消毒丹加减方治疗 Hp 感染的慢性萎缩性胃炎的临床疗效和安全性观察
- Author:
Gang CHEN
- Publication Type:Journal Article
- Keywords:
Chronic gastritis;
Hp infection;
Pixu shire syndrome;
Ganluxiaodu micropills;
Curative effect
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(10):1445-1449
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy and safety of Ganluxiaodu micropills in treatment of helicobacter pylori(Hp)infected chronic atrophic gastritis.Methods 120 patients with chronic atrophic gastritis (pixu shire syndrome)from April 2013 to April 2014 were selected and divided into observation group and the control group (n =60)according to random number table method.The control group was given standard triple therapy,the observation group was given Ganluxiaodu micropills on the basis of the control group,7 days for a period of treatment. The symptoms changes of the two groups before and after treatment were observed and combined results of the gastro-scope and breath test,determined the clinical curative effect and eradication rate of Hp.The SF -36 scale score was used to evaluate the quality of life of the patients.Results The clinical symptom scores[(15.92 ±2.25)points vs (16.12 ±2.14)points ],SF -36 scale [(68.05 ±12.98)points vs (65.77 ±11.34)points]of the two groups before treatment had no statistically significant differences (t =-1.033,-1.239,all P >0.05).The clinical symp-tom scores and SF -36 score of the observation group and the control group after treatment [(8.24 ±1.23)points, (89.44 ±12.93)points;(12.65 ±1.75)points,(77.43 ±11.59)points ]were obviously improved than before treat-ment,the differences were statistically significant (t =2.574,2.765,2.133,2.047,all P <0.05);the observation group improved significantly better than the control group,the difference was statistically significant (t =2.394, 2.432,all P <0.05 ).The total effective rates of observation group and control group were 96.7% and 83.3%respectively,Hp eradicate rates were 93.3%,70.0% respectively,which in the observation group were significantly higher than the control group,the differences were statistically significant(χ2 =4.282,4.098,all P <0.05).There were no serious adverse reaction happened in the two groups,the incidence rate of adverse reactions of the two groups (11.67% vs 8.33%)had no statistically significant difference (χ2 =1.032,P >0.05).Conclusion Ganluxiaodu micropills can improve the Hp eradicate rate of standard triple therapy,the clinical efficacy of Ganluxiaodu micropills in treatment of Hp infected chronic atrophic gastritis (pixu shire syndrome)is significant,which is worthy of clinical popularization and application.
