Expression of c -Met in gastrointestinal stromal tumor and its clinical significance

VernacularTitle:c-Met 蛋白在胃肠间质瘤组织中的表达及其临床意义
Author: Chaoqun WANG ; Bifei HUANG ; Yan WANG ; Qian WANG ; Xinxin SUN ; Yue ZENG ; Junkang SHAO ; Dandan WU
Publication Type:Journal Article
Keywords: c-Met; GIST; Immunohistochemistry
From: Chinese Journal of Primary Medicine and Pharmacy 2016;23(10):1453-1455
CountryChina
Language:Chinese
Abstract: Objective To study the expression of c -Met protein in gastrointestinal stromal tumor(GIST) and to evaluate its clinicopathological significance.Methods The immunohistochemical technique,EnVision method was used to evaluate the expression of c -Met in 105 cases of GISTs.Results c -Met protein positive rate in GISTs was 9.52%(10 /105),its expression rate was significantly higher in GISTs with >10 /50HPF mitotic activity(P <0.05).c -Met protein expression rate was higher in GISTs which >5cm,moderate or high -risk,or mass located outside the stomach,but the difference was not statistically significant(P >0.05 ).Conclusion c -Met protein expression may related with risk of GISTs.We think that c -Met is worthy of further study for its potential usage as a evaluation indicators of GISTs clinicobiological behavior.