Observation of the clinical effects of Jiawei Jinhuang powder with fumigation -washing applied for hand-foot skin reaction caused by sorafenib

VernacularTitle:加味金黄散熏洗预防索拉菲尼所致手足皮肤反应的疗效观察
Author: Chaofu ZHU ; Zhuohong LI ; Qiang LI ; Dan LI ; Baiping AN
Publication Type:Journal Article
Keywords: Hand -foot skin reaction; Jiawei Jinhuang powder; Sorafenib
From: Chinese Journal of Primary Medicine and Pharmacy 2016;23(10):1510-1512
CountryChina
Language:Chinese
Abstract: Objective To investigate associate chief physician the clinical effects of Jiawei Jinhuang powder with fumigation -washing on hand -foot skin reaction(HFSR)caused by sorafenib.Methods 48 patients who received sorafenib were randomly divided into two groups.24 patients in the treatment group were administered Jiawei Jinhuang powder with fumigation -washing,and another 24 patients in the control group were given VitB6 orally.After 8 weeks,the incidence and grade of HFSR were statistically studied between the two groups.Results There was significant differences of hand -foot reaction between the treatment group and the control group (incidence rate:29.17% vs 70.83%,χ2 =8.375,P <0.05;The incidence rate of Ⅱ -Ⅲ:12.50% vs 33.33%,P <0.05 ). Conclusion Jiawei Jinhuang powder with fumigation -washing could remarkably reduce the incidence rate of HFSR caused by sorafenib.