Influence of trimetazidine on left cardiac systolic function and plasma brain natriuretic peptide in alcoholic cardiomyopathy
10.3760/cma.j.issn.1008-6706.2016.10.039
- VernacularTitle:曲美他嗪对酒精性心肌病左心收缩功能和血浆脑钠肽的影响
- Author:
Xiaoxu WANG
;
Xiaonan WANG
;
Wenchao WANG
- Publication Type:Journal Article
- Keywords:
Alcoholic cardiomyopathy;
Trimetazidine;
Left heart contraction;
Plasma brain natriuretic peptide
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(10):1578-1581
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of trimetazidine on left cardiac systolic function and plasma brain natriuretic peptide(BNP)in alcoholic cardiomyopathy.Methods 60 cases of alcoholic cardiomyopathy in our hospital from December 2014 to December 2015 were chosen to research,and they were divided into observation group and control group by random number table,30 patients in each group.The control group was treated with bisoprolol combined with strengthening heart,diuretic and other treatment,the observation group was treated with trimetazidine on the basis of routine treatment.Left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter (LVEDD),each sub output(CO)after 6 months'treatment were compared.Results LVEF of the observation group was from pre -treatment (34.8 ±5.4)% up to (47.4 ±5.5)%,LVEDD value (49.1 ±6.5)min and CO values (5.6 ±0.7)L/min were significantly better than the control group[(53.4 ±7.5)min,(4.9 ±0.7)L/min],the differences were statistically significant(t =2.373,3.873,all P <0.05).BNP level of the observation group after treatment was significantly lower than control group[(455.8 ±133.2)fmoL/mL vs (542.7 ±128.3)fmoL/mL,t =2.574,P <0.05)].The total effective rate of the observation group (96.67%)was higher than that of the control group (80%),and the difference between the two groups was significant (χ2 =13.09,P <0.05 ).Conclusion Alcoholic cardiomyopathy should pay attention to the daily scientific daily routine,take measure to quit smoking and alcohol.Trimetazidine could effectively improve the left ventricular systolic function,decrease the level of BNP,thus is worthy of clinical application.
