A novel amorphous calcium phosphate drug-eluting stent：its biocompatibility after implantation into mini-swine coronary artery
10.3969/j.issn.2095-4344.2016.16.010
- VernacularTitle:新型纳米材料无定形磷酸钙药物支架置入小型猪冠状动脉后的生物相容性
- Author:
Zheng TAN
;
Li LI
;
Yi MA
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2016;20(16):2354-2359
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:As previously reported, poly-L-lactic acid stents have been mostly used as coronary artery stents, but this stent has a lack of early support force and produces some acidic products that wil induce local vascular inflammatory reactions.
OBJECTIVE:To explore the biocompatibility of a novel amorphous calcium phosphate drug-eluting stent, after implantation into mini-swine coronary artery.
METHODS:Twenty mini-swine were randomly equivalently divided into observation group and control group. The right femoral arteries of animals were separated layer by layer and the new type of biodegradable stent and poly-L-lactic acid stent were implanted, respectively.
RESULTS AND CONCLUSION:The vessel lumes in the two groups were smooth and unobstructed showed by coronary artery angiography immediately after implantation. At 4 weeks after implantation, the coronary angiography showed the patency of vessel lumens with no stent thrombosis and stenosis in both two groups. The C-reactive protein levels in the two groups had no significant differences before and 4 weeks after stent implantation. At 4 weeks after implantation, the number of lymphocytes and inflammatory score in the observation group were significantly higher than those in the control group, but the neointimal area and percentage of stenosis area had no significant difference between the two groups. These results indicate that the novel amorphous calcium phosphate drug-eluting stent after implantation into mini-swine coronary artery has good biocompatibility.
