Early and midterm follow-up of vascular endothelial function in children with surgical repair for coarctation of aorta

VernacularTitle:主动脉缩窄矫治术后血管内皮功能近中期随访
Author: Jiemin ZENG ; Ping HUANG ; Hongying WANG ; Yanfei WANG ; Jia YUAN ; Li ZHANG ; Xinxin CHEN ; Hujun CUI ; Liling JIN
Publication Type:Journal Article
Keywords: Coarctation of aorta; Flow-mediated dilation; Early surgery
From: The Journal of Practical Medicine 2016;32(8):1247-1249
CountryChina
Language:Chinese
Abstract: Objective To evaluate the endothelium-dependent vasodilation in children after repair for coarctation of aota (CoA). Methods A group of 20 children having undergone CoA repair between January 2010 and October 2010 in Guangzhou Women and Children′s Medical Center were include in the study , including 12 infants aged less than 6 months and 8 ones aged more than 6 months. Another 20 healthy children were enrolled during the same period as controls. All the subjects underwent monitoring of resting blood pressure and flow-mediated dilation (FMD) of the brachial artery in 4-year follow-up. Results There were no resting hypertension in all subjects , but FMD in the CoA group was higher than in the control group and so it was with the early surgery group and non early surgery group. Conclusion The surgical repair for coarctation of aorta could not cure the vascular function impairment satisfactorily , neither is the early surgery effective in alleviating the injuries in vascular endothelia.