Correlation of carotid intima-media thickness with platelet parameters and markers of platelet activation in patients with type 2 diabetes mellitus
10.3969/j.issn.1006-5725.2016.08.015
- VernacularTitle:血小板参数及活化标志物与2型糖尿病患者颈动脉内膜中层厚度的相关性
- Author:
Yunxiao QU
;
Zhixin JIANG
;
Tenglong HAN
;
Lili WANG
;
Delu GAO
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Plateletparameters;
Urinary 11-dehydro-thromboxane B2;
Carotid intima-media thickness
- From:
The Journal of Practical Medicine
2016;32(8):1250-1253
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the correlation between platelet parameters , platelet activation marker and carotid intima-media thickness (CIMT) in patients with type 2 diabetes mellitus. Methods One hundred and ninety-five type 2 diabetic patients were enrolled in this study. The patients were divided into the normal control group, the CIMT increased group and the clot group according to the carotid intima-media thickness. Levels of platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), platelet hematocrit(PCT), urinary 11-dehydro-thromboxane B2 (11-DH-TXB2) and other clinical, biochemical characteristics were measured. Results (1) Levels of serum LDL-C, MPV, PDW, urinary 11-DH-TXB2 and clinical course in the clot group were higher than those in the CIMT increased group and the normal control group (P < 0.05). (2) Compared with the normal control group, the clinical course, serum LDL-C, MPV, PDW and urinary 11-DH-TXB2 were higher in the CIMT increased group (P < 0.05). (3) By using with spearman rank correlation test, carotid intima-media thickness was positively associated with age , course , BMI , GLU , GHbA1C , LDL-C , MPV , PDW and urinary 11-DH-TXB2, whereas carotid intima-media thickness was negative associated with HDL-C, PLT (both P < 0.05). (4) MPV, PDW and urinary11-DH-TXB2 were shown as the independent risk factors for CIMT. Conclusions Platelet activation marker and platelet parameters are associated with carotid intima-media thickness in patients with type 2 diabetes mellitus.
