Impact of human papillomavirus multi-infections on the risk of high-grade squamous intraepithelial lesion and invasive cervical cancer
10.3969/j.issn.1006-5725.2016.08.020
- VernacularTitle:人乳头状瘤病毒多重感染对高度鳞状上皮内病变和宫颈癌发生的影响
- Author:
Hongxia ZHAO
;
Yanshuang DONG
;
Youzhi CAI
;
Yingjun ZHU
- Publication Type:Journal Article
- Keywords:
HPV multi-infections;
Invasive cervical cancer;
HSIL;
LSIL
- From:
The Journal of Practical Medicine
2016;32(8):1268-1270
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the incidence rate of HPV infection or multi-infections at different stages of cervical lesions in the development of cervical cancer , and the impact of specific types of HPV multi-infections on the risk of cervical cancer. Methods 103 samples of cervical tissues were detected and then divid-ed into ICC/HSIL group and LSIL/NILMF group according to the degree of pathological changes. HPV type was determined by PCR product sequencing. E6 nested multiplex PCR was performed to detect HPV multi-infections. Odds ratios were calculated to determinate the association between the sample category (LSIL/NILM or ICC/HSIL) and the specific types of HPV multi-infections. Results In HPV-positive samples, the rate of multi-in-fections had no significant differences between the two groups. Coinfection of HPV68 with HPV16 increased the risk of ICC/HSIL, as compared with HPV16 or HPV68 infection alone. Conclusions High-risk HPV coinfec-tions has a higher risk to induce ICC/HSIL than does HPV infection alone.
