The change of the serum myeloperoxidase and lipoxin A4 in patients with coronary heart disease
10.3760/cma.j.jssn.1673-4904.2016.04.019
- VernacularTitle:冠心病患者血清髓过氧化物酶和脂氧素A4的变化
- Author:
Siyu LIANG
;
Hongkai XIAO
;
Xiangping LI
- Publication Type:Journal Article
- Keywords:
Coronary artery disease;
Inflammation;
Myeloperoxidase;
Lipoxin A4
- From:
Chinese Journal of Postgraduates of Medicine
2016;39(4):354-358
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes and significance of the serum myeloperoxidase (MPO) and lipoxin (LXA4) in patients with coronary heart disease (CHD). Methods From December 2010 to February 2011,143 patients with CHD (CHD group) and 44 patients without CHD (control group) were selected. The serum high sensitive C-reactive protein (hs-CRP), MPO and LXA4 levels were assessed, and the ratio of MPO and LXA4 (M/L) was calculated. These indexes were compared between 2 groups. The influencing factors of MPO, LXA4 and M/L levels were analyzed by multifactor Logistic regression analysis. Results The serum levels of hs-CRP, LXA4, MPO, and M/L in CHD group were significantly higher than those in control group: 3.25 mg/L vs. 0.99 mg/L, 229.88 ng/L vs. 178.63 ng/L, 422.58 U/L vs. 186.85 U/L and (1.78 ± 0.52) U/ng vs. (1.02 ± 0.17) U/ng, and there were statistical differences (P<0.05). Multifactor Logistic regression analysis result showed: LXA4 level, unstable angina, acute myocardial infarction and severe elevation of white blood cell count were the impact factors for the elevation of MPO (P<0.01 or<0.05);there were no correlations between MPO level and stable angina, mild and midrange elevation of white blood cell count (P>0.05). MPO was the impact factor for the increase of LXA4 (P<0.01), and stable angina was the impact factor for the decline of LXA4 (P =0.019);there were no correlations between LXA4 level and unstable angina, acute myocardial infarction and other factors (P>0.05). Stable angina, unstable angina and acute myocardial infarction were the impact factors for the elevation of M/L (P<0.01); there were no correlations between M/L and other factors (P>0.05). Conclusions The inflammatory response in patients with CHD is accompanied by the presence of inflammation and resolution imbalance.
