Expression and clinical significance of serum response factor and vascular endothelial growth factor receptor 2 in gastric carcinoma
10.3760/cma.j.issn.1006-9801.2016.02.010
- VernacularTitle:胃癌血清应答因子和血管内皮生长因子受体2的表达及其临床意义
- Author:
Min ZHAO
;
Hui ZHANG
;
Ying ZHOU
;
Jiangmei HUANG
;
Ruiji LIU
- Publication Type:Journal Article
- Keywords:
Gastric carcinoma;
Serum response factor;
Vascular endothelial growth factor receptor 2
- From:
Cancer Research and Clinic
2016;28(2):112-115
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of serum response factor (SRF) and vascular endothelial growth factor receptor (VEGFR2) in gastric carcinoma. Methods SABC immunohistochemical method was used to determine the expressions of SRF and VEGFR2 in 50 cases of gastric carcinoma, 50 cases of surgery incisal edges and 29 cases of lymph node metastasis focus. Results The detection positive rates of SRF and VEGFR2 in gastric carcinoma were 52.00 % (26/50) and 60.00 %(30/50), respectively, which were significantly higher than those in the normal gastric mucosa [16.00 % (8/50) and 10.00 % (5/50), respectively] (P< 0.05), with no statistical difference with metastiatic lymph node [65.52 % (19/29) and 72.41 % (21/29), respectively]. In the gastric carcinoma group, the expression of SRF was relevant with depth of invasion and lymph node metastasis (P<0.05). The expression of VEGFR2 was not related to age, gender and tumour size (P>0.05), but closely correlated to differentiation degree, invasion depth and lymph node metastasis (P<0.05). The expressions of SRF and VEGFR2 in the gastric carcinoma were positively correlated (r= 0.594, P< 0.05). Conclusion Overexpressions of SRF and VEGFR2 in gastric carcinoma can be regarded as the poorly prognostic markers and play an important role in invasion and metastasis of gastric carcinoma.
