Research progress of non-receptor tyrosine kinase signal transducer and activator of transcription as a new target in colon cancer
10.3760/cma.j.issn.1006-9801.2016.02.016
- VernacularTitle:非受体酪氨酸激酶-信号转导和转录激活因子信号通路作为结肠癌治疗新靶点的研究进展
- Author:
Linlin QU
;
Wei XU
- Publication Type:Journal Article
- Keywords:
Colon neoplasms;
Non receptor tyrosine kinase signal transducer and activator of transcription;
Inflammation;
Molecular targeted therapy
- From:
Cancer Research and Clinic
2016;28(2):129-132
- CountryChina
- Language:Chinese
-
Abstract:
Malignant colon cells require angiogenesis and optimal tumor microenvironment for proliferation, invasion and metastasis. The non-receptor tyrosine kinase signal transducer and activator of transcription (JAK-STAT) pathway are involved in multiple processes, including chronic inflammation-associated tumorigenesis, cancer proliferation, tumor angiogenesis, immune evasion and facilitating tumor metastasis, making JAK-STAT a new target in molecular target therapy. In this review, advances on JAK-STAT pathway as a new target in colon tumorigenesis are updated, and a preliminary estimation of JAK-STAT in prognosis and target therapy will be mentioned to show a potential future of JAK-STAT in colon cancer.
