Research progress of application of E-cadherin, N-cadherin and vimentin in tumor metastasis

VernacularTitle:E-钙黏蛋白、N-钙黏蛋白及波形蛋白在肿瘤转移中应用的研究进展
Author: Meng LI ; Jiubin WU ; Peitong ZHANG
Publication Type:Journal Article
Keywords: Epithelial-mesenchymal transition; Neoplasms; E-cadherin; N-cadherin; Vimentin
From: Cancer Research and Clinic 2016;28(2):132-136
CountryChina
Language:Chinese
Abstract: The invasion and metastasis of tumor as the primary cause of death in cancer increases not only the patient's suffering, but also the difficulty of clinical treatment. It is an important guiding to find the molecular biological tumor markers and gene targets of antirecurrence and antimetastasis for clinical treatment. The invasion and metastasis of tumor is a complex process including the biological characteristics of the cancer, interaction among host cells, extracellular matrix and cancer cells, etc. Recently, epithelial mesenchymal transition (EMT) is becoming a hot spot in oncology research by virtue of its effect on genesis and development of tumor. Currently, the known markers of EMT include epithelial marker proteins mainly containing E-cadherin and interstitial marker proteins mainly containing N-cadherin and vimentin. It is necessary to make a summary among the studies on three proteins.