Research progress of multi-functional cancer killing cytokine, interleukin-24 in tumors
10.3760/cma.j.issn.1006-9801.2016.02.018
- VernacularTitle:多功能抗癌基因白细胞介素24在肿瘤中的研究进展
- Author:
Zengyu JIANG
;
Wenna HOU
;
Sheng HE
- Publication Type:Journal Article
- Keywords:
Interleukin-24;
Neoplasms;
Apoptosis;
Gene
- From:
Cancer Research and Clinic
2016;28(2):136-140
- CountryChina
- Language:Chinese
-
Abstract:
Interleukin-24 (IL-24) is a member of IL-10 family, which was cloned from human melanoma cells by the method of subtractive hybridization. IL-24 can inhibit the growth of tumor cells and angiogenesis and enhance radiation sensitivity and immune adjustment with non-toxic effects on normal cells.As a kind of cytokine with multiple anti-tumor functions, IL-24 will become a new weapon of gene therapy against cancer. The application and mechanism of IL-24 in the treatment of cancer will be discussed in this paper.
