Effects of Curcuma Oil Emulsion on the Hyperplasia of Mammary Glands in Rats
10.3870/j.issn.1004-0781.2016.03.003
- VernacularTitle:莪术油乳膏对大鼠乳腺增生的作用?
- Author:
Wenjing LI
;
Defu CAI
;
Yingcai NIU
;
Xiaoming LI
;
Chengchong LI
;
Yu ZOU
;
Bo HONG
- Publication Type:Journal Article
- Keywords:
Curcuma oil emulsion;
Hyperplasia,mammary glands;
Pathomorphology
- From:
Herald of Medicine
2016;(3):229-232
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of external use of Curcuma oil on the hyperplasia of mammary glands in rats and explore the mechanism. Methods Sixty female Wistar rats were randomly divided into following groups:normal con-trol group, model control group, Sanjierubi plaster group, low-, medium- and high-dose curcuma oil emulsion groups ( n=10 each).The models of hyperplasia of mammary glands were established by intramuscular injection of estradiol benzoate and proges-terone into the medial part of the rat hind limb.Different doses of medicines were given for 4 consecutive weeks.Enzyme-linked im-munosorbent assay, HE staining and immunohistochemistry were used to investigate the action mechanism of curcuma oil emulsion against mammary gland hyperplasia. Results Curcuma oil emulsion had preventive and therapeutic effects on the hyperplasia of mammary glands.The diameter of breasts was significantly reduced, the body weight restored, serum estradiol, follicle-stimulating hormone and prolactin levels profoundly decreased, progesterone, testosterone and luteinizing hormone levels markedly increased and the number and diameter of lobular acini obviously reduced in high-dose curcuma oil emulsion group when compared with those in model control group (P<0.05 or P<0.01). Conclusion Curcuma oil emulsion can remarkably improve the disturb-ance of serum hormones and inhibit the occurrence of hyperplasia of mammary glands.
