Analgesic and Anti-inflammatory Effects of the Water Extract of Glycosmis citrifolia (Willd.) Lindl
10.3870/j.issn.1004-0781.2016.03.004
- VernacularTitle:山桔叶水提物镇痛抗炎作用?
- Author:
Lizhen HUANG
;
Ningning HOU
;
Wenfang MA
;
Haijing WU
;
Xiuzhen DENG
;
Biao TANG
- Publication Type:Journal Article
- Keywords:
Water extract of Glycosmis citrifolia (Willd.) Lindl.;
Analgesic;
Anti-inflammatory
- From:
Herald of Medicine
2016;(3):233-236
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the analgesic and anti-inflammatory effects of the water extract of Glycosmis citrifolia (Willd.) Lindl.on mice and explore the mechanism. Methods The analgesic and anti-inflammatory effects were evaluated by 0.7% acetic acid-induced writhing test,the hot plate test,tests of dimethylbenzene-induced ear swelling,1% carrageenan-induced paw edema,determination of PGE2 in inflammatory feet,0.6% acetic acid-induced increase in peritoneal capillary permeability and cotton ball granuloma. Results The water extract of Glycosmis citrifolia (Willd.) Lindl.at low,medium and high doses can reduce the acetic acid-induced writhing times (P<0.01 or P<0.05),increase the pain threshold of mice (P<0.01 or P<0.05), inhibit dimethylbenzene-induced ear swelling (P<0.01 or P<0.05),1% carrageenan-induced paw edema (P<0.01 or P<0.05) and PGE2 production (P<0.01),0.6% acetic acid-induced increase of peritoneal capillary permeability (P<0.05),and the de-velopment of cotton ball granuloma (P<0.01 or P<0.05). Conclusion The water extract of Glycosmis citrifolia (Willd.) Lindl.shows analgesic and anti-inflammatory effects on mice.
