Research for correlation between CYP 4F2 gene polymorphism and coronary heart disease in Mongolian patients
10.3969/j.issn.1008-0074.2016.01.05
- VernacularTitle:CYP4F2基因多态性与蒙古族冠心病的相关性研究
- Author:
Ping ZHAO
;
Peiye CHANG
;
Jinglong NAN
;
Peng JIANG
;
Rile GE
;
Jiming XIE
- Publication Type:Journal Article
- Keywords:
Genes;
Mongolia;
Polymorphism,single nucleotide
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2016;25(1):18-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship between CYP4F2 gene polymorphism and coronary heart disease (CHD) in Mongolia patients ,and investigate clinical characteristics of these patients . Methods:All subjects received questionnaire . Gene amplification and genotyping were performed in 234 Mongolian CHD patients (CHD group) and 221 non-CHD pa‐tients (normal control group) using high temperature ligase detection reaction technique .The relationship between Mongo‐lian CHD and CYP4F2 gene polymorphisms of two single nucleotide polymorphism (SNP) sites (rs1558139 ,rs2108622) was analyzed .Results:Compared with normal control group ,there were significant rise in percentages of male (41.18% vs . 67.95% ) ,smoking history (32.13% vs .41.88% ) ,body mass index [BMI ,(21.66 ± 4.53 ) kg/m2 vs .(25.34 ± 5.37 ) kg/m2 ] and triglyceride level [ (1.66 ± 0.90) mmol/L vs .(1.92 ± 1.38) mmol/L] ,and significant reduction in level of high density lipoprotein cholesterol [ (1.18 ± 0.28) mmol/L vs .(1.07 ± 0.29) mmol/L] in CHD group , P<0.05 or <0.01.There were no significant difference in genotype and allele frequencies of rs 1558139 and rs2108622 between two groups . Conclusion:Clinical characteristics of Mongolian CHD patients include high male percentage ,smoking history ,high body mass index and high triglyceride level .CYP4F2 gene polymorphisms of rs1558139 and rs2108622 are not related to coronary heart disease in Mongolian patients .
