Research progress of 1,2-diIinoIeyIoxy-3-dimethy Iaminopropane-based cat-ionic Iipid nanoparticIe
10.11665/j.issn.1000-5048.20160117
- VernacularTitle:1，2-二亚油酸-3-二甲基氨丙烷类阳离子脂质纳米粒的研究进展
- Author:
Yue HU
;
Zhou CHEN
;
Xiaoxing LUO
;
Xiaoyan XUE
- Publication Type:Journal Article
- Keywords:
DLinDMA;
gene vector;
lipid nanoparticles
- From:
Journal of China Pharmaceutical University
2016;(1):112-117
- CountryChina
- Language:Chinese
-
Abstract:
Cationic lipid nanoparticles possessing favorable biocompatibility and controllable particle size has at-tracted increasing attention in the field of non-viral vectors for delivering nucleic acids in vitro and in vivo.1,2-Dilinoleyloxy-3-dimethylaminopropane(DLinDMA)and its derivatives,one of the most important cationic lipid materials,have been widely studied as the mainly composition of cationic lipid nanoparticels.This paper summa-rized the structure,characteristics and clinical application of DLinDMA nanoparticles.
