Advances in Iipid-Iowering effect of PPARαagonists
10.11665/j.issn.1000-5048.20160118
- VernacularTitle:PPARα激动剂降血脂作用的研究进展
- Author:
Yue HU
;
Jun XU
;
Yanhua LIU
;
Zengtao WANG
;
Liming HUANG
;
Jialong FANG
;
Chen WANG
- Publication Type:Journal Article
- Keywords:
peroxisome proliferator-activated receptor α;
agonists;
reducing blood lipid;
advances
- From:
Journal of China Pharmaceutical University
2016;(1):118-124
- CountryChina
- Language:Chinese
-
Abstract:
Peroxisome proliferator-activated receptor α(PPARα)is an important subtype in the PPARs family. PPARs are a group of nuclear hormone receptors,which belong to type II nuclear receptor super family.PPARαagonists could be used in the treatment of hyperlipemia in clinic.PPARαagonists mainly include natural type and synthetic type,and according to the structure,the synthetic PPARαagonists can be divided into phenyl-heterocy-clic derivatives,ureide derivatives,amides derivatives,phenyloxazole or phenylthiazole derivatives,etc.So far, many PPARαagonists have been approved or in clinical development,and a series of novel PPARαagonists with higher activity and selectivity are being developed.This review will survey the progress in PPARαagonists.
