Expression and correlation of tumor-associated macrophages and CCL5 in ganstric cancer

VernacularTitle:肿瘤相关巨噬细胞和CCL5在胃癌中的表达及其相关性研究
Author: Haixia DING ; Lianmei ZHAO ; Baoen SHAN
Publication Type:Journal Article
Keywords: Ganstric cancer; Tumor associated macrophages( TAM); CCL5
From: Chinese Journal of Immunology 2016;(1):74-78
CountryChina
Language:Chinese
Abstract: Objective:To study the expression and correlation of tumor-associated macrophages(TAM) and CCL5 in ganstric cancer.Methods:48 cases patients with completed clinical and pathological data of gastric cancer paraffin block specimens were select-ed.Cancer tissues and adjacent tissues were used as control,using SP immunohistochemical method to detect CD68 and CCL5 in gastric cancer tissues and adjacent tissues,and using the Spearman correlation statistics statistical methods for the correlation.Results:CD68 and CCL5 showed positive expression in gastric cancer tissue,significantly higher than those in the adjacent tissues(P<0.01),CD68 and CCL5 were related with gastric cancer invasion depth, lymph node metastasis, TNM stage and tumor differentiation ( P<0.001 ) . There was positive relation between the expression of CD68 and CCL5 in gastric cancer(P<0.01,r=0.759).Conclusion: CD68 and CCL5 played a driving role to the invasion and metastasis of gastric cancer occurrence,suggesting that the secretion CCL5 by TAM may promote the invasion and metastasis of gastric cancer.