The recent research of pathogenesis of IgA nephropathy
10.16571/j.cnki.1008-8199.2016.02.002
- VernacularTitle:IgA 肾病的遗传易感性和黏膜免疫应答异常
- Author:
Jinquan WANG
- Publication Type:Journal Article
- Keywords:
IgA nephropathy;
Genetic riskfactor;
Intestinal immunity;
Pathogenesis
- From:
Journal of Medical Postgraduates
2016;(2):120-125
- CountryChina
- Language:Chinese
-
Abstract:
It is known that genetic risk factors and mucosal immunity play vary important role in the pathogenesis of IgA ne-phropathy ( IgAN) .Recent years, new susceptibility loci of IgAN and relationships among genetic risk factors and each field of IgAN, which includes onset, clinical manifestation, histopathology, response to treatment and prognosis, have been found.Meanwhile, a re-surgence of interest has addressed the role of intestinal immunity facing dietary components, like gluten or the complex intestinal flora, the microbiota.A defective immune tolerance might favor an abnormal response to microbiota with alterations of the intestinal barrier, including increased alimentary antigens and bacterial toxins absorption, triggering mucosal-associated lymphoid tissue ( MALT) activa-tion and subclinical intestinal inflammation.The genetic pathogenesis and the new hypothesis for a strong intestine-kidney connection in IgAN are tempting, because they offer new treatment options, such as targeted to subclinical intestinal inflammation or microbiota modi-fications, and favor for further exploring new targets of IgAN intervention.
