Genomics in Alzheimer′s disease
10.13220/j.cnki.jipr.2016.01.001
- VernacularTitle:阿尔茨海默病基因组学研究
- Author:
Hongxing LEI
- Publication Type:Journal Article
- Keywords:
Alzheimer′s disease;
genome;
transcriptome;
epigenome;
drug discovery
- From:
Journal of International Pharmaceutical Research
2016;(1):1-7
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer′s disease(AD)is a major form of neurodegenerative disease. Due to the lack of effective treatment for AD,drug discovery is imminent,and genomics has become a driving force for the drug discovery. Genomic studies of AD involve sever?al aspects,such as large-scale studies on the genetic risk,brain transcriptome studies,and epigenetic studies. Notable progress has been made in genomic studies of AD,which has facilitated the drug discovery. In the meantime,biomarkers for early diagnosis includ?ing those from peripheral blood have emerged as a major research topic because early detection and intervention are the prominent task for the moment. Research progress in this field will be briefly reviewed. Because of the vast heterogeneity in AD pathogenesis ,genom?ics will also provide strong support for precision medicine in the future.
