Advances in genome-wide association studies of sporadic Alzheimer′s disease
10.13220/j.cnki.jipr.2016.01.002
- VernacularTitle:全基因组关联分析散发性阿尔茨海默病的研究进展
- Author:
Rui LU
;
Shenglian YANG
;
Yizheng WANG
- Publication Type:Journal Article
- Keywords:
Alzheimer′s disease;
genome-wide association study(GWAS);
risk gene
- From:
Journal of International Pharmaceutical Research
2016;(1):8-14
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer′s disease(AD)is a neurodegenerative disorder resulted from complicate interactions between genes and environment. There is no effective therapy so far. The genome-wide association study(GWAS)provides the opportunity to discover the risk genes of sporadic AD,which is informative for revealing the pathogenesis of AD and guiding new drug development. In this re?view,we summarize the current findings of genetic studies of AD,the risk genes and their biological relevance with AD,and new drug development strategy supported by genetic studies.
