Insulin signaling pathway and glucose metabolism in Alzheimer′s diseases
10.13220/j.cnki.jipr.2016.01.005
- VernacularTitle:大脑胰岛素信号通路与葡萄糖代谢在阿尔茨海默病中的作用与关系
- Author:
Dong LI
;
Yan HUANG
;
Wenxia ZHOU
;
Yongxiang ZHANG
- Publication Type:Journal Article
- Keywords:
Alzheimer′s diseases;
insulin signaling pathway;
glucose metabolism;
glucose transport
- From:
Journal of International Pharmaceutical Research
2016;(1):26-32
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer′s disease(AD)is a degenerative metabolic disease,whose exact pathological mechanism still remains unknown. Currently,studies have found that patients in AD accompany with insulin signaling pathway impairment and cerebral glu?cose metabolism dysfunction. As insulin signaling pathway and cerebral glucose metabolism homeostasis play a key role in AD ,some researches consider AD as“typeⅢdiabetes”. This review aims to discuss the alteration of cerebral insulin signaling pathway and glu?cose metabolism in AD,as well as their relationship with AD. We will also elaborate the advance in anti-AD drugs based on cerebral insulin signaling pathway.
