Contribution of luteinizing hormone to Alzheimer′s disease
10.13220/j.cnki.jipr.2016.01.009
- VernacularTitle:黄体生成素在阿尔茨海默病发病机制中的作用
- Author:
Jianhui WANG
;
Xiaorui CHENG
;
Wenxia ZHOU
;
Yongxiang ZHANG
- Publication Type:Journal Article
- Keywords:
Alzheimer′s disease;
luteinizing hormone(LH);
cognition;
aging;
gonadal hormone
- From:
Journal of International Pharmaceutical Research
2016;(1):50-55
- CountryChina
- Language:Chinese
-
Abstract:
Luteinizing hormone(LH)is a gonadotropin of hypothalamic-pituitary-gonadal axis(HPG),secreted by the anteri?or pituitary. The secretion of LH is directly controlled by the release of gonadotropin releasing hormone(GnRH),acts at the ovaries and testes to stimulate the production of gonadal hormones. Aging leads to increases in LH,and higher serum levels of LH has been ob?served in Alzheimer′s disease(AD)patients when compared to age-matched controls. Evidences from basic research and epidemiologi?cal investigation support the critical role of elevated LH in pathogenic process of AD and deteriorating cognitive decline. Here we sum?marize the recent discoveries containing human AD epidemiological evidence for LH,cognitive impairments resulting from LH activi?ty,LH in AD pathology and LH receptor signaling mechanisms.
