Advances in novel anti-neurodegenerative diseases drugs targeting mitochondria
10.13220/j.cnki.jipr.2016.01.012
- VernacularTitle:靶向线粒体抗神经退行性疾病新型药物研究进展
- Author:
Jing SUN
;
Jing GAO
- Publication Type:Journal Article
- Keywords:
neurodegenerative diseases;
mitochondria-targeting agents;
mitochondrial dysfunction
- From:Journal of International Pharmaceutical Research
2016;(1):79-86
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondria,the major organelle in neurons,which provides energy via oxidative phosphorylation for all kinds of metabolic activities,is involved in many pathophysiological processes,such as calcium homeostasis and apoptosis. Increasing evi?dence has indicated that mitochondrial dysfunction displays a significant role in the early stage of neurodegenerative disorders like Par?kinson′s disease(PD)and Alzheimer′s disease(AD). Therefore,studies which focus on mitochondrial dysfunction under these patho?logical conditions contribute to understanding the pathogenesis of neurodegenerative disorder and discovering new neuroprotective drugs. Actually,various mitochondria-targeting agents have been tried in clinic or under different investigational phases against neuro?degenerative disorders. This review discusses the evidence on mitochondrial impairments during neurodegenerative diseases and the advances in mitochondria-targeting agents as a potential alternative drug strategy for effective management of neurodegenerative diseases.
