Advances in anti-Parkinson′s disease drugs and their related pharmacological targets

VernacularTitle:抗帕金森病药物及其作用靶点研究进展
Author: Xue ZHANG ; Wen ZHANG ; Lida DU ; Li GAO ; Guanhua DU
Publication Type:Journal Article
Keywords: Parkinson′s disease; anti-Parkinson′s disease drugs; pharmacological targets
From: Journal of International Pharmaceutical Research 2016;(1):87-96
CountryChina
Language:Chinese
Abstract: Parkinson′s disease(PD),the second neurodegenerative disease in the world,is characterized by a combination of motor symptoms(rest tremor,bradykinesia,rigidity,postural instability,stooped posture and freezing of gait)and non-motor symp?toms(including psychiatric and cognitive disorders). The core neuropathological features of PD are the loss of dopaminergic neurons in the substantia nigra and the deposition of iron and cytoplasmic protein aggregates(Lewy bodies)inside neurons. Currently,clinical treatment for PD is symptomatic and there is no effective treatment to restore neuronal degeneration. In the PD therapy ,medication re?mains dominant. Anti-PD drugs are mainly based on the critical signal pathways or some specific targets which play a key role in the pathogenesis of PD to relieve the symptoms of PD. Research and development in novel drugs to prevent or treat PD have been a crucial subject,and some novel candidates are under development. In this paper,we summarize and analyze the anti-PD drugs,and make a brief discussion about its pharmacological targets.