Clinical effect analysis of supraclavicular lymph node metastasis of esophageal cancer by chemoradi-ation therapy
- VernacularTitle:同步放化疗治疗食管癌锁骨上淋巴结转移的临床疗效分析
- Author:
Guifang ZHANG
;
Lingxin MENG
;
Zhaojun DING
- Publication Type:Journal Article
- Keywords:
Esophageal cancer;
Supraclavicular lymph node;
Concurrent chemotherapy;
3D-CRT
- From:
Journal of Chinese Physician
2015;(z2):8-12
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical curative effect,survival rate and adverse reactions of three-dimensional conformal radiotherapy(3D-CRT )in combination with chemotherapy on lymph nodes metastasis of esophageal carcinoma.Methods Using supraclavicular 3D-CRT combined with chemotherapy on and simple 3D-CRT supraclavicular lymph node metastasis of esophageal cancer patients,3D-CRT com-bined synchronous chemotherapy (treatment group),51 cases,only 3D-CRT 49 cases (control group).3D-CRT combined synchronous chemotherapy 51 cases (treatment group),simple 3D-CRT 49 cases (control group).These patients 3D-CRT were given the total dose of 50 ~60Gy/25 ~30F.TN chemotherapy regi-mens were applied:paclitaxel 135 mg/m2 ,d1;Nedaplatin 25 mg/m2 ,d1,1 ~3,21 days cycle in fist week and fourth week.Results Local control and treatment group survival rates in 1,2 year were significantly higher than that of control group (P <0.05).Treatment group adverse reaction rate is higher than the con-trol group,but there was no statistically significant difference.Conclusions The recent curative effect and survival rate could be significantly improved by 3D-CRT joint TN synchronous chemotherapy regimen for pa-tients with supraclavicular lymph node metastasis of esophageal cancer,but the relatively high incidence of adverse reactions,clinical application should be considered comprehensively according to actual situation.
